Which medications in the drug class Antidepressant, Tricyclic are used in the treatment of Brachioradial Pruritus?

Updated: Oct 05, 2020
  • Author: Julianne Mann, MD; Chief Editor: Dirk M Elston, MD  more...
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Antidepressant, Tricyclic

Amitriptyline (Elavil)

Amitriptyline is an analgesic for certain chronic and neuropathic pain. It blocks the reuptake of norepinephrine and serotonin, which increases concentration in the CNS. It decreases pain by inhibiting spinal neurons involved in pain perception. Amitriptyline is highly anticholinergic. It is often discontinued because of somnolence and dry mouth.

Cardiac arrhythmia, especially in overdose, has been described; monitoring QTc interval after reaching target level is advised. Up to 1 month may be needed to obtain clinical effects.

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