What is the role of botulinum toxin A in the treatment of brachioradial pruritus?

Updated: Oct 05, 2020
  • Author: Julianne Mann, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

One report describes dramatic improvement after injections with botulinum toxin A (100 IU/3 mL saline) in a 59-year-old white woman with longstanding brachioradial pruritus. [42] This patient received 4 series of injections and experienced significant improvement for 6 months following each series of injections. The authors point out that acetylcholine has been shown to be a mediator of itch in patients with atopic dermatitis, and they suggest that reduction in acetylcholine release mediated by botulinum toxin A may explain its helpfulness in the setting of brachioradial pruritus. They also postulate that botulinum toxin A may reduce histamine-mediated itch.


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