How does chronic sun exposure affect the pathogenesis of brachioradial pruritus?

Updated: Oct 05, 2020
  • Author: Julianne Mann, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Many patients with brachioradial pruritus have a history of chronic sun exposure. [2, 15, 16] Kestenbaum and Kalivas [17] postulated that histamine release from mast cells in response to chronic sun exposure might play a pathophysiologic role; they reported a patient with brachioradial pruritus and an elevated serum histamine level.

In some cases, sun exposure has been reported to exacerbate symptoms and photoprotection has been reported to provide amelioration. [4, 18, 19, 20]


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