What is the role of nerve fibers in the pathogenesis of brachioradial pruritus?

Updated: Oct 05, 2020
  • Author: Julianne Mann, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Wallengren and Sundler [12] used neuronally directed antibodies to show that patients with brachioradial pruritus have reduced numbers of dermal and epidermal nerve fibers, and, moreover, that this reduction in cutaneous innervation only occurs during symptomatic flares. [13] De Ridder et al demonstrated selective C-fiber dysfunction at C6-8 using quantitative sensory testing in a patient with brachioradial pruritus, with improvement of C-fiber functionality after intralaminar C6-7 steroid injection. [14] Increased skin perfusion on the affected forearm as measured by Doppler imaging has also been reported. [11]


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