At what age do complement deficiencies typically present?

Updated: Apr 28, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Michael A Kaliner, MD  more...
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Answer

Individuals with complement deficiencies that hinder opsonization often present at an early age (months to a few years) because of increased susceptibility to overwhelming infection.

Patients with deficiencies in formation of the MAC tend to present when slightly older (late-teenage years).

Complement deficiencies associated with immune complex diseases, such as SLE, do not show a clear pattern of age at first presentation.


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