What are the racial predilections of complement deficiencies?

Updated: Apr 28, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Michael A Kaliner, MD  more...
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Answer

While no definitive racial patterns of association have been established for the majority of complement deficiencies, ethnic predispositions have been described for certain complement deficiencies. For example, deficiencies in properdin and C2 have been associated with the white race, C6 deficiencies have been shown to have a possible predisposition in African populations, and deficiencies in C8 and C9 have been associated with an Asian racial background. More specifically, 2 functionally distinct C8 deficiency states have been described: C8 alpha-gamma deficiency seen mostly in persons of Afro-Caribbean, Hispanic, and Japanese descent; and C8beta, mainly evident in persons of Caucasian descent. [10] However, for most of these deficiencies, the absolute number of patients studied has been quite small.


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