Which medications in the drug class Immunosuppressants are used in the treatment of Cold Agglutinin Disease?

Updated: Dec 02, 2020
  • Author: Salman Abdullah Aljubran, MD; Chief Editor: Michael A Kaliner, MD  more...
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The metabolites of immunosuppressive alkylating agents cross-link DNA, thereby interfering with cell proliferation. These agents are not needed in patients with idiopathic cold agglutinin disease. Immunosuppressant agents also include antibodies directed against the CD20 antigen found on the surface of B-lymphocytes.


This agent is chemically related to nitrogen mustards. As an alkylating agent, the mechanism of action of the active metabolites may involve cross-linking of DNA, which may interfere with growth of normal and neoplastic cells. Cystitis can develop with long-term administration, and the leukemogenic potential should be kept in mind. The primary (idiopathic) form of cold agglutinin disease is unlikely to require use of this class of drugs.

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