Which medications in the drug class Corticosteroids are used in the treatment of Cold Agglutinin Disease?

Updated: Dec 02, 2020
  • Author: Salman Abdullah Aljubran, MD; Chief Editor: Michael A Kaliner, MD  more...
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These agents elicit anti-inflammatory and immunosuppressive properties, causing profound and varied metabolic effects. They modify the body's immune response to diverse stimuli.


This agent is an immunosuppressant used for the treatment of autoimmune or lymphoproliferative disorders. Prednisone modulates lymphocytes and decreases antibody production. It is frequently used with alkylating agents.

Prednisone may decrease inflammation by reversing increased capillary permeability and suppressing polymorphonuclear leukocyte activity. It stabilizes lysosomal membranes and suppresses lymphocyte and antibody production. Prednisone may be beneficial in certain cases with low-titer cold agglutinin of high thermal amplitude.

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