Which medications in the drug class Immunomodulators are used in the treatment of Cold Agglutinin Disease?

Updated: Aug 28, 2018
  • Author: Salman Abdullah Aljubran, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

Immunomodulators

Interferons have had variable success in cold agglutinin–induced hemolytic anemia. Expense and serious adverse effects are issues to consider up front before choosing this class of drug. Interferons are used in the treatment of lymphoproliferative disorders.

Interferon alfa-2b (Intron-A)

Interferon alfa is manufactured by recombinant DNA technology. Its mechanism of effect is not clearly understood. However, direct antiproliferative effects against many different kinds of malignant cells have been shown in clinical disease states (eg, lymphoma, melanoma, chronic granulocytic leukemia), and modulation of the host immune response may play an important role.


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