Which histologic findings are characteristic of cold agglutinin disease?

Updated: Aug 28, 2018
  • Author: Salman Abdullah Aljubran, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

Depending on the underlying precipitating illness, changes may be seen in the bone marrow and lymph nodes of patients with cold agglutinin disease. The presence of a malignant lymphoproliferative disorder may also be evident in biopsy samples. Clumps of RBCs may be observed in the peripheral smear. (See the images below.)

Peripheral blood smear showing several clumps of R Peripheral blood smear showing several clumps of RBCs with the largest in the center. These are typical of aggregates seen in persons with cold agglutinin disease.
Blood smear showing spherocytic and agglutinated r Blood smear showing spherocytic and agglutinated red blood cells.

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