What is the role of blood typing in the workup of cold agglutinin disease?

Updated: Aug 28, 2018
  • Author: Salman Abdullah Aljubran, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

Blood typing is performed in the event that a transfusion is needed. The presence of autoantibodies may interfere with blood typing because they may react with the RBCs of potential donors, making detection of alloantibodies difficult. Several techniques are available to improve compatibility testing. These include testing the patient's serum for anti-A and anti-B hemagglutinins and performing the compatibility testing reactions at 37°C to avoid inaccurate test results due to nonspecific agglutination in the cold.


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