Which neoplasms are associated with cold agglutinin disease?

Updated: Aug 28, 2018
  • Author: Salman Abdullah Aljubran, MD; Chief Editor: Michael A Kaliner, MD  more...
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Neoplasms may be associated with a cold agglutinin or a cryoglobulin, giving rise to symptoms of Raynaud syndrome. If the cold agglutinin titer is elevated and a complement-specific Coombs test result is positive, the patient may have a neoplastic clone of lymphocytes producing the cold agglutinin disease. This would be important in terms of therapy and prognosis, because the underlying lymphoma may be responsive to treatment. Often, the more severe forms of cold agglutinin disease are associated with lymphoid malignancy. [47]

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