What are the possible complications of cold agglutinin disease?

Updated: Aug 28, 2018
  • Author: Salman Abdullah Aljubran, MD; Chief Editor: Michael A Kaliner, MD  more...
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Complications of cold agglutinin disease include the following:

  • Brisk hemolysis due to cold exposure

  • Ischemic complications at exposed sites due to prolonged cold exposure

  • Other symptoms related to severe anemia

  • Infrequently, development of malignant disease during follow-up care of a patient with idiopathic chronic cold agglutinin disease

  • Shock or congestive heart failure, resulting from severe hemolysis and anemia

  • Peripheral gangrene and, rarely, fatalities after inadvertent and perhaps prolonged exposure to the cold

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