What causes cold agglutinin disease?

Updated: Aug 28, 2018
  • Author: Salman Abdullah Aljubran, MD; Chief Editor: Michael A Kaliner, MD  more...
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Classic chronic cold agglutinin disease is idiopathic, associated with symptoms and signs in relation to cold exposure. Causes of the monoclonal secondary disease include the following:

Causes of polyclonal secondary cold agglutinin disease include the following:

  • Mycoplasma infections - M pneumoniae [30]

  • Viral infections - Infectious mononucleosis due to Epstein-Barr virus (EBV) or CMV

  • Viral infections, other - Mumps, varicella, rubella, adenovirus, HIV, influenza, hepatitis C

  • Bacterial infections - Legionnaire disease, syphilis, listeriosis, Escherichia coli

  • Parasitic infections - Malaria, trypanosomiasis

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