Which factors are needed to induce active hemolytic anemia in cold agglutinin disease?

Updated: Aug 28, 2018
  • Author: Salman Abdullah Aljubran, MD; Chief Editor: Michael A Kaliner, MD  more...
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Several factors play a role in determining the ability of a cold agglutinin to induce an active hemolytic anemia. [4, 1] These include the following:

  • Ability to initiate
  • Extent of antibody-induced complement activation
  • Concentration of the antibody
  • Range of temperatures, including the highest temperature at which the antibody interacts with the RBC (its thermal amplitude)
  • Qualitative binding of IgM to the RBC
  • Modification of the antibody's ability to fix complement components onto the RBCs

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