How is cold agglutinin disease treated?

Updated: Aug 28, 2018
  • Author: Salman Abdullah Aljubran, MD; Chief Editor: Michael A Kaliner, MD  more...
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Idiopathic cold agglutinin disease is usually benign, and most patients need only take protective measures against cold temperatures. Case studies report benefit from treatment with rituximab or the complement inhibitor eculizumab. RBC transfusion is indicated in severe, acute disease. Glucocorticoids are generally not useful in IgM-induced cold agglutinin disease but may occasionally work in selected patients. The presence of an associated malignancy requires specific therapy. See Treatment and Medication.

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