Which medications in the drug class Corticosteroids are used in the treatment of Anaphylaxis?

Updated: May 16, 2018
  • Author: S Shahzad Mustafa, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

Corticosteroids

Corticosteroids have a delayed onset of action and do not reverse the cardiovascular effects of anaphylaxis. These agents should be used in severe reactions, but the use of epinephrine and H1 antihistamines has a higher priority. It is unclear whether corticosteroids administered systemically during the initial phase of anaphylaxis can weaken or prevent late-phase reactions. [77]

While corticosteroids usually are administered IV in patients with anaphylaxis for presumed rapidity of effect, PO and IV corticosteroids are equally efficacious in asthma therapy. When administered acutely, corticosteroids commonly are continued for 2-3 days. In asthma treatment, large parenteral doses customarily are administered acutely, followed by lower PO dosing for varying periods. Long-acting parenteral preparations may be administered as an alternative and have been shown effective in asthma therapy.Optimal dosage range for corticosteroids has not been established; thus, a range of dosages is provided based on published recommendations.

Methylprednisolone (Solu-Medrol)

Methylprednisolone may help prevent late-phase allergic reactions (biphasic anaphylaxis). It has no immediate effects.

Prednisone

Prednisone is an immunosuppressant for treatment of allergic reactions. It may decrease inflammation by reversing increased capillary permeability and suppressing PMN activity.


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