What is the role of a controlled food challenge of in the evaluation of anaphylaxis?

Updated: May 16, 2018
  • Author: S Shahzad Mustafa, MD; Chief Editor: Michael A Kaliner, MD  more...
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Thus, the detectable presence of specific IgE in the skin or serum can confirm a clinical suspicion formed by compatible patient history and examination. However, undetectable specific IgE occasionally occurs in patients with food allergy and therefore further evaluation (eg, physician-supervised oral food challenge is necessary in cases in which the history is highly suggestive before informing a patient that he or she is not allergic to a suspected food and may ingest it). The double-blind, placebo –controlled food challenge is considered the criterion standard for diagnosis, but a physician-supervised single-blind or an open-food challenge may be considered diagnostic in certain circumstances. These areas are reviewed in depth in the 2010 NIAID-sponsored expert panel report on the diagnosis and management of food allergy in the United States. [66]

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