What is the significance of baseline levels of total tryptase in the evaluation of anaphylaxis?

Updated: May 16, 2018
  • Author: S Shahzad Mustafa, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

Recent reports concerning insect sting anaphylaxis suggest closer scrutiny to baseline total tryptase levels, especially in patients who experienced hypotension during anaphylaxis, might be appropriate. [60, 61, 62] Higher baseline tryptase concentrations (>11.4 µg/L) may indicate mastocytosis or a monoclonal mast cell disorder (eg, c-kit mutation) and may require bone marrow biopsy and cytogenetic analysis for further evaluation. [61, 62]


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