What is the incidence of anaphylaxis in the US?

Updated: May 16, 2018
  • Author: S Shahzad Mustafa, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

A population-based study from Rochester, Minnesota, found an average annual incidence of anaphylaxis of 58.9 cases per 100,000 person-years, which had increased from 46.9 cases per 100,000 in 1990. [11] Of identified causes, ingestion of a specific food was responsible for 33%, insect stings for 18.5%, and medications for 13.7%. Twenty-five percent of cases were considered idiopathic. Episodes of anaphylaxis occurred more frequently from July through September, a difference that is attributable to insect stings.

In a study of patients referred to a university-affiliated allergy-immunology practice in Memphis, Tennessee, food was the cause of anaphylaxis in 34% of patients, medications in 20%, and exercise in 7% (anaphylaxis due to insect stings or SCIT was excluded from the study). [29] The cause could not be determined in 59% (ie, they were diagnosed with idiopathic anaphylaxis). A separate study estimated that there are 20,000-47,000 cases of idiopathic anaphylaxis in the United States per year (approximately 8-19 episodes per 100,000 person-years).


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