What is idiopathic anaphylaxis?

Updated: May 16, 2018
  • Author: S Shahzad Mustafa, MD; Chief Editor: Michael A Kaliner, MD  more...
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Idiopathic anaphylaxis is a syndrome of recurrent anaphylaxis for which no consistent triggers can be determined despite an exhaustive search. [23] This recurrent syndrome should be distinguished from a single episode of anaphylaxis for which the etiology may be unclear.

Idiopathic anaphylaxis can be categorized as infrequent (< 6 episodes per year) or frequent (≥6 episodes per year or 2 or more episodes within the last 2 months). [23] One approach is expectant treatment with epinephrine, antihistamines, and prednisone for individuals who have infrequent episodes and a prolonged taper of prednisone for those with frequent episodes.

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