Which agents cause direct, nonimmunologic release of anaphylaxis mediators?

Updated: May 16, 2018
  • Author: S Shahzad Mustafa, MD; Chief Editor: Michael A Kaliner, MD  more...
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Certain agents, including opioids, dextrans, protamine, and vancomycin, are thought to cause direct, nonimmunologic release of mediators from mast cells. Evidence also exists that dextrans and protamine can activate several inflammatory pathways, including complement, coagulation, and vasoactive (kallikrein-kinin) systems.

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