What is the etiological relationship between anaphylaxis and systemic mastocytosis?

Updated: May 16, 2018
  • Author: S Shahzad Mustafa, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

Anaphylaxis can be a manifestation of systemic mastocytosis, a disease characterized by excessive mast cell burden in multiple organs. Such patients appear to be at increased risk for food and venom reactions. Alcohol, vancomycin, opioids, radiocontrast media, and other biologic agents that can directly degranulate mast cells are generally discouraged in these patients.


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