What immunologic immunoglobulin E (IgE)-independent reactions cause anaphylaxis?

Updated: May 16, 2018
  • Author: S Shahzad Mustafa, MD; Chief Editor: Michael A Kaliner, MD  more...
  • Print
Answer

Anaphylaxis may result from administration of blood products, including IV immunoglobulin, or animal antiserum, at least partly as a consequence of activation of the complement cascade. Certain byproducts of the cascade are capable of causing mast cell/basophil degranulation. (See Pathophysiology.)


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!