What is the mortality rate of allergen-specific subcutaneous immunotherapy (SCIT) caused anaphylaxis?

Updated: May 16, 2018
  • Author: S Shahzad Mustafa, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

Allergen-specific subcutaneous immunotherapy (SCIT) can cause IgE-mediated anaphylaxis. Allergy injections are a common trigger for anaphylaxis. This is not unexpected, because the treatment is based on injecting an allergen to which the patient is sensitive. However, life-threatening reactions are rare. Three studies suggest that fatalities from SCIT occur at a rate of approximately 1 death per 2,500,000 injections. [20, 21, 22] A total of 104 fatalities due to SCIT and skin testing were reported from 1945-2001.


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