Which mediators are released in anaphylaxis?

Updated: May 16, 2018
  • Author: S Shahzad Mustafa, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

When mast cells and basophils degranulate, whether by IgE- or non–IgE-mediated mechanisms, preformed histamine and newly generated leukotrienes, prostaglandins, and platelet-activating factor (PAF) are released. In the classic form, mediator release occurs when the antigen (allergen) binds to antigen-specific IgE attached to previously sensitized basophils and mast cells. The mediators are released almost immediately when the antigen binds.


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