Which types of anaphylaxis do not involve immunoglobulin E (IgE)?

Updated: May 16, 2018
  • Author: S Shahzad Mustafa, MD; Chief Editor: Michael A Kaliner, MD  more...
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Other types of immunologic anaphylaxis do not involve IgE. For example, anaphylaxis resulting from administration of blood products, including intravenous immunoglobulin, or animal antiserum is due, at least in part, to complement activation. Immune complexes formed in vivo or in vitro can activate the complement cascade. Certain byproducts of the cascade—plasma-activated complement 3 (C3a), plasma-activated complement 4 (C4a), and plasma-activated complement 5 (C5a)—are called anaphylatoxins and can cause mast cell/basophil degranulation.

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