What are lipid-derived mediators involved in the pathogenesis of anaphylaxis?

Updated: May 16, 2018
  • Author: S Shahzad Mustafa, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

Additional mediators include newly generated lipid-derived mediators such as prostaglandin D2, leukotriene B4, and platelet-activating factor (PAF), as well as the cysteinyl leukotrienes, such as LTC4, LTD4, and LTE4. These mediators further contribute to the proinflammatory cascade seen in anaphylaxis.


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