How is anaphylaxis categorized?

Updated: May 16, 2018
  • Author: S Shahzad Mustafa, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

The traditional nomenclature for anaphylaxis reserves the term anaphylactic for reactions mediated by immunoglobulin E (IgE) and the term anaphylactoid for non-IgE-mediated reactions, which can be clinically indistinguishable. The World Allergy Organization has recommended replacing this terminology with immunologic (IgE-mediated and non–IgE-mediated [eg, IgG and immune complex complement–mediated]) and nonimmunologic anaphylaxis (events resulting in sudden mast cell and basophil degranulation in the absence of immunoglobulins). [4]


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