Which medications in the drug class Immunosuppressive agents are used in the treatment of Alloimmunization From Transfusions?

Updated: Sep 08, 2017
  • Author: Douglas Blackall, MD, MPH; Chief Editor: Michael A Kaliner, MD  more...
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Answer

Immunosuppressive agents

Inhibit activity of the immune system.

Immunoglobulin intravenous IVIG (Gamunex, Iveegam EN, Gammagard)

Fractionated human immunoglobulins treated to inactivate viruses and filtered to eliminate high molecular weight complexes. Neutralizes circulating myelin antibodies through antiidiotypic antibodies. Promotes remyelination. May increase CSF IgG (10%). Down-regulates proinflammatory cytokines, including INF-gamma. Blocks Fc receptors on macrophages. Suppresses inducer T and B cells and augments suppressor T cells. Blocks complement cascade.


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