Which medications in the drug class Cytotoxic agents are used in the treatment of Alloimmunization From Transfusions?

Updated: Sep 08, 2017
  • Author: Douglas Blackall, MD, MPH; Chief Editor: Michael A Kaliner, MD  more...
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Answer

Cytotoxic agents

Inhibit immune cell growth and proliferation.

Vincristine (Oncovin)

Only one report describes effectiveness in an 18-mo-old child with platelet refractoriness. Several reports, however, describe its use for treating autoimmune thrombocytopenia. Use for platelet alloimmunization remains investigational.

Cyclosporin A (Sandimmune, Neoral)

Two reports describe use in patients with aplastic anemia and platelet refractoriness. Both patients dramatically improved in response to platelet transfusions after treatment. Use for platelet alloimmunization remains investigational.


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