What is the role of medications in the treatment of alloimmunization from transfusions?

Updated: Sep 08, 2017
  • Author: Douglas Blackall, MD, MPH; Chief Editor: Michael A Kaliner, MD  more...
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Immunosuppressive agents such as IVIG can provide short-term benefit in patients with platelet refractoriness resulting from alloimmunization. Consider using cytotoxic agents only in patients clearly unresponsive to all other treatment modalities. Only physicians familiar with the use and toxicity of cytotoxic agents should prescribe these drugs, as there is only anecdotal support for their use in alloimmunization. In other words, this indication is considered investigational.

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