Which conditions are included in the differential diagnoses of delayed hemolytic transfusion reactions (DHTR)?

Updated: Sep 08, 2017
  • Author: Douglas Blackall, MD, MPH; Chief Editor: Michael A Kaliner, MD  more...
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Paroxysmal nocturnal hemoglobinuria

Warm autoimmune hemolytic anemia

Cold agglutinin disease

Paroxysmal cold hemoglobinuria

Nonimmune hemolysis

  • Sepsis (particularly clostridial species), malaria, babesiosis

  • Mechanical hemolysis (eg, prosthetic valve, left ventricular assist device, small phlebotomy needles, infusion pumps, other devices)

  • Infusion of incompatible solutions together with RBC units

  • Accidental freezing or excessive heating of RBC units

  • Microangiopathic hemolytic anemia

  • Drug-induced hemolysis

  • Congenital hemolytic anemia (eg, glucose-6-phosphate dehydrogenase deficiency, hereditary spherocytosis)

Reabsorption of hematoma (eg, high lactate dehydrogenase or bilirubin, low haptoglobin)

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