Which physical findings are characteristic of alloimmunized refractoriness to platelet transfusions?

Updated: Sep 08, 2017
  • Author: Douglas Blackall, MD, MPH; Chief Editor: Michael A Kaliner, MD  more...
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Frequently, patients with refractoriness to platelet transfusion are asymptomatic and diagnosed by laboratory methods; however, failure to achieve hemostatic levels of platelets may preclude these patients from important procedures, including bone marrow transplantation. Alloimmunization should be avoided in candidates for bone marrow transplantation.

Preexisting bleeding resulting from thrombocytopenia may persist after transfusion of an appropriate therapeutic dose of platelets. [9] Rarely, spontaneous bleeding may occur after prophylactic transfusion of platelets.

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