Which medications in the drug class Leukotriene receptor antagonists are used in the treatment of Allergic Rhinitis?

Updated: Dec 26, 2018
  • Author: Javed Sheikh, MD; Chief Editor: Michael A Kaliner, MD  more...
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Leukotriene receptor antagonists

Alternative to oral antihistamine to treat allergic rhinitis. One of the leukotriene receptor antagonists, montelukast (Singulair), has been approved in the United States for treatment of seasonal and perennial allergic rhinitis. [88, 89, 90] When used as single agent, produces modest improvement in allergic rhinitis symptoms. [91]

Montelukast (Singulair)

Selective leukotriene receptor antagonist that inhibits the cysteinyl leukotriene (CysLT 1) receptor. Selectively prevents action of leukotrienes released by mast cells and eosinophils. When used as a single agent, has been shown to result in a reduction of seasonal allergic rhinitis symptoms, similar in degree to that of loratadine.

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