What are the symptoms of fixed drug eruptions (FDE)?

Updated: Oct 09, 2020
  • Author: David F Butler, MD; Chief Editor: Dirk M Elston, MD  more...
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Local symptoms may include pruritus, burning, and pain. [1] Systemic symptoms are uncommon, but fever, malaise, nausea, diarrhea, abdominal cramps, anorexia, and dysuria have been reported. [48, 17]

Further questioning may reveal prior episodes of fixed drug eruption, atopic disease, or other past drug reactions. Family history may render a history of atopy, drug reactions, or diabetes mellitus. [1]

Several cases of fixed drug eruption on the genitalia have been reported in patients who were not ingesting the drug but whose sexual partner was taking the offending drug and the patient was exposed to the drug through sexual contact. [49, 50, 51]

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