Which factors predict a poor prognosis for melanoma?

Updated: Mar 08, 2019
  • Author: Jonathan B Heistein, MD; Chief Editor: Gregory Gary Caputy, MD, PhD, FICS  more...
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Answer

Answer

Poor prognostic factors include the following:

  • Tumor thickness (worse prognosis in thicker lesions)

  • Evidence of tumor in regional lymph nodes (stage III disease)

  • Higher number of positive lymph nodes

  • Presence of distant metastasis (stage IV disease)

  • Anatomic site (trunk and/or face lesions have worse prognoses than extremity lesions)

  • Presence of ulceration

  • Presence of regression on histologic examination (controversial)

  • Male sex


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