What is fibroepithelial tumor of Pinkus?

Updated: Oct 07, 2019
  • Author: Guy J Petruzzelli, MD, PhD, MBA, FACS; Chief Editor: Gregory Gary Caputy, MD, PhD, FICS  more...
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Answer

Answer

The fibroepithelial tumor of Pinkus is best considered a type of basal cell carcinoma (BCC). Originally identified by Herman Pinkus in the 1950s, the premalignant fibroepithelial tumor of Pinkus is a distinctive tumor that predominantly occurs on the lower trunk and thighs, often appearing as pedunculated lesions resembling fibromas. These tumors typically develop between the fourth and sixth decade of life.

Histologically, the tumor is composed of epithelial cells resembling basal cells surrounded by a fibrous stroma. [17]  With further cellular characterization, Heenen and colleagues demonstrated that these basal-like epithelial cells have different cell cycle characteristics in comparison with normal epithelial cells. [18]  It is suggested that this dysregulation of the cell cycle is a premalignant phenomenon and represents the potential progression into a transformed, cancerous cell. In rare cases, these faint-staining epithelial cells are replaced by more aggressive, smaller, dark-staining basaloid cells. These new basaloid cells eventually overtake the lesion, consequently, developing into an invasive basal cell epithelioma.


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