What is pyoderma gangrenosum?

Updated: Jan 30, 2020
  • Author: Ginard I Henry, MD; Chief Editor: Gregory Gary Caputy, MD, PhD, FICS  more...
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While pyoderma gangrenosum (see the image below) is associated with ulcerative colitis, 50% of the time it occurs without inflammatory bowel disease. [42]

Pyoderma gangrenosum. Pyoderma gangrenosum.

Other associations include ulcer diathesis, diverticular disease, rheumatoid arthritis, pulmonary and hematologic illnesses, and carcinoid tumors. The lesions typically are ulcers with rolled borders. Physiologically, the wound is more like a progressive vasculitis than an infection. However, gram-positive and gram-negative bacteria species have been cultured from these chronic wounds. Streptococcal and Proteus species appear to be involved frequently.

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