What are histological features of discoid lupus erythematosus?

Updated: Jan 30, 2020
  • Author: Ginard I Henry, MD; Chief Editor: Gregory Gary Caputy, MD, PhD, FICS  more...
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Histologically, these lesions are characterized by a hyperkeratosis with some atrophy of the epidermis and degeneration of the basal layer. However, none of the histologic findings are pathognomonic. A band of lymphocytic infiltrates can be found along the dermal-epidermal junction. Melanin pigmentation may be discontinuous in extending to the papillary dermis. The follicles and other adnexa tend to be surrounded with an intense lymphocytic infiltrate. Periodic acid-Schiff (PAS) stains demonstrate thickening of the epidermal basement membrane; however, this is nonspecific.

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