What is the composition of neurofibromas?

Updated: Jan 30, 2020
  • Author: Ginard I Henry, MD; Chief Editor: Gregory Gary Caputy, MD, PhD, FICS  more...
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Neurofibromas are composed of Schwann cells, fibroblasts, perineurial cells, masts cells, and axons embedded in extracellular matrix. The lesions present as discrete but unencapsulated tumors. A neurofibroma is composed of interlacing fascicles of Schwann cells that have irregular, wavy, elongated nuclei. The nerve’s perineurium is disrupted, which suggests a breakdown of appropriate signaling between Schwann cells, fibroblasts, and perineurial cells. The part played by each cell type in neurofibroma formation is unclear. On gross inspection, the neurofibroma tumor usually has small fibers coursing through its substance.

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