What is the presentation of neurofibromas?

Updated: Jan 30, 2020
  • Author: Ginard I Henry, MD; Chief Editor: Gregory Gary Caputy, MD, PhD, FICS  more...
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Answer

Answer

Neurofibromas can present as solitary lesions or as multiple lesions. Multiple neurofibromas can be associated with neurofibromatosis (usually neurofibromatosis type 1 [NF-1], also called von Recklinghausen disease of the skin). Patients with NF-1 also present with classic brown-colored macules called café-au-lait macules. Lesions are soft and can be invaginated when compressed with a fingertip (known as the buttonhole sign). Cutaneous neurofibromas usually remain asymptomatic, but neurofibromas that develop in major peripheral or central nerves can cause motor or sensory dysfunction.


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