What causes sebaceous adenoma (SA)?

Updated: Jan 30, 2020
  • Author: Ginard I Henry, MD; Chief Editor: Gregory Gary Caputy, MD, PhD, FICS  more...
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Answer

Answer

The etiology of sebaceous adenomas is unclear, but Muir-Torre syndrome is related to a genetic truncating germline mutation. An autosomal dominant inherited germline mutation in one of the DNA mismatch repair genes, most commonly hMSH2, is associated with the syndrome. It is inherited, with a high degree of penetrance and variable expression, with a male-to-female ratio of 3:2.


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