What causes seborrheic keratosis (SK)?

Updated: Jan 30, 2020
  • Author: Ginard I Henry, MD; Chief Editor: Gregory Gary Caputy, MD, PhD, FICS  more...
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These lesions are usually asymptomatic. However, if multiple lesions suddenly occur with or without pruritus, this may be a sign of internal malignancy. Although a rare occurrence, a sudden eruption of seborrheic keratosis lesions that is correlated with internal malignancy is called the Leser-Trelat sign. The validity of the association has recently come into question, but an abrupt development of seborrheic keratoses in a younger person should be investigated for a possible gastrointestinal neoplasm.

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