What is nevus sebaceus of Jadassohn?

Answer

Nevus sebaceus of Jadassohn is a congenital, yellowish plaque seen on the head and neck. While this lesion often is included in tumors of the skin adnexum, it is actually an epithelial nevus. On histopathology, nevus sebaceus of Jadassohn, or verrucous epidermal nevi (some consider a variant), has a papillomatosis appearance with acanthosis, sebaceous hyperplasia and often absent hair follicles. The lesion tends to enlarge and become more warty in appearance with time.

A nevus sebaceus of Jadassohn is shown in the image below.

Macular benign skin lesion: Nevus sebaceous of Jadassohn.

View Media Gallery

Tumors may arise in nevus sebaceus over time; however, the majority of tumors are benign. The most common two benign tumors which develop are syringocystadenoma papilliferum and trichoblastoma. Rarely, malignant tumors, predominantly basal cell carcinoma, can develop in nevus sebaceus. Nevus sebaceus lesions tend to be yellowish orange, waxy, hairless plaques. An accelerated growth phase may be observed during adolescence secondary to changes in the hormonal milieu.

Did this answer your question?

Yes No

Additional feedback? (Optional)

Thank you for your feedback!

Moore RB, Fagan EB, Hulkower S, Skolnik DC, O'Sullivan G. Clinical inquiries. What's the best treatment for sebaceous cysts?. J Fam Pract. 2007 Apr. 56(4):315-6. [Medline].
Lipoff JB, Chatterjee K. Acrochordon. 2017 Jun. [Medline]. [Full Text].
Lipoff JB, Masood S, Chatterjee K. Acrochordon. StatPearls. 2020 Jan. [Medline]. [Full Text].
Paolino G, Donati M, Didona D, Mercuri SR, Cantisani C. Histology of Non-Melanoma Skin Cancers: An Update. Biomedicines. 2017 Dec 20. 5 (4):[Medline]. [Full Text].
Takai T. Advances in histopathological diagnosis of keratoacanthoma. J Dermatol. 2017 Mar. 44 (3):304-14. [Medline]. [Full Text].
Savage JA, Maize JC Sr. Keratoacanthoma clinical behavior: a systematic review. Am J Dermatopathol. 2014 May. 36(5):422-9. [Medline].
Touchi R, Ueda K, Kurokawa N, Tsuji M. Central regions of keloids are severely ischaemic. J Plast Reconstr Aesthet Surg. 2016 Feb. 69 (2):e35-41. [Medline].
Robles DT, Moore E, Draznin M, Berg D. Keloids: pathophysiology and management. Dermatol Online J. 2007 Jul 13. 13(3):9. [Medline].
van Leeuwen MC, van der Wal MB, Bulstra AE, et al. Intralesional cryotherapy for treatment of keloid scars: a prospective study. Plast Reconstr Surg. 2015 Feb. 135(2):580-9. [Medline].
Mourad B, Elfar N, Elsheikh S. Spray versus intralesional cryotherapy for keloids. J Dermatolog Treat. 2016 Jun. 27 (3):264-9. [Medline].
Wang CJ, Ko JY, Chou WY, Cheng JH, Kuo YR. Extracorporeal Shockwave Therapy for Treatment of Keloid Scars. Wound Repair Regen. 2018 Jan 13. [Medline].
Papp DF, Khanna AJ, McCarthy EF, Carrino JA, Farber AJ, Frassica FJ. Magnetic resonance imaging of soft-tissue tumors: determinate and indeterminate lesions. J Bone Joint Surg Am. 2007 Oct. 89 Suppl 3:103-15. [Medline].
Braun RP, Rabinovitz H, Oliviero M, Kopf AW, Saurat JH. Dermoscopic diagnosis of seborrheic keratosis. Clin Dermatol. 2002 May-Jun. 20(3):270-2. [Medline].
Greco MJ, Mahabadi N, Gossman W. Seborrheic Keratosis. StatPearls. 2020 Jan. [Medline]. [Full Text].
Kim WJ, Lee WK, Song M, et al. Clinical clues for differential diagnosis between verruca plana and verruca plana-like seborrheic keratosis. J Dermatol. 2015 Jan 9. [Medline].
Wollina U. Recent advances in managing and understanding seborrheic keratosis. F1000Res. 2019. 8:[Medline]. [Full Text].
Baumann LS, Blauvelt A, Draelos ZD, et al. Safety and efficacy of hydrogen peroxide topical solution, 40% (w/w), in patients with seborrheic keratoses: Results from 2 identical, randomized, double-blind, placebo-controlled, phase 3 studies (A-101-SEBK-301/302). J Am Acad Dermatol. 2018 Nov. 79 (5):869-77. [Medline]. [Full Text].
Ferrandiz C, Plazas MJ, Sabate M, Palomino R, EPIQA Study Group. Prevalence of actinic keratosis among dermatology outpatients in Spain. Actas Dermosifiliogr. 2016 Oct. 107 (8):674-80. [Medline]. [Full Text].
Tokez S, Alblas M, Nijsten T, Pardo Cortes LM, Wakkee M. Predicting keratinocyte carcinoma in patients with actinic keratosis: development and internal validation of a multivariable risk prediction model. Br J Dermatol. 2019 Dec 19. [Medline].
Chamli A, Zaouak A. Bowenoid Papulosis. StatPearls. 2020 Jan. [Medline]. [Full Text].
Matsumoto AJ, Schmitt AR, Skelley LM, Baum CL. Factors Influencing Squamous Cell Carcinoma In Situ Recurrence and Implications for Treatment Choice. Dermatol Surg. 2017 Nov 6. [Medline].
Watanabe R, Kawai K, Ito M, Ito K, Ikeda K. Sebaceous epithelioma. J Dermatol. 1994 Jan. 21(1):35-41. [Medline].
Elgart GW. Seborrheic keratoses, solar lentigines, and lichenoid keratoses. Dermatoscopic features and correlation to histology and clinical signs. Dermatol Clin. 2001 Apr. 19(2):347-57. [Medline].
Siqveland E, Pond D. Neurofibromatosis type 1: update on a common genetic condition. Minn Med. 2009 Mar. 92(3):49-52. [Medline].
Osmancevic A, Landin-Wilhelmsen K, Larkö O, Wennberg AM, Krogstad AL. Vitamin D production in psoriasis patients increases less with narrowband than with broadband ultraviolet B phototherapy. Photodermatol Photoimmunol Photomed. 2009 Jun. 25(3):119-23. [Medline].
Dunwell P, Rose A. Study of the skin disease spectrum occurring in an Afro-Caribbean population. Int J Dermatol. 2003 Apr. 42(4):287-9. [Medline].
Sigmon JR, Yentzer BA, Feldman SR. Calcitriol ointment: a review of a topical vitamin D analog for psoriasis. J Dermatolog Treat. 2009. 20(4):208-12. [Medline].
Al-Kudwah AJ, Feldman SR. Management of Psoriasis. South Med J. 2009 May 7. [Medline].
Wu JJ. Contemporary management of moderate to severe plaque psoriasis. Am J Manag Care. 2017 Dec. 23 (21 Suppl):S403-16. [Medline]. [Full Text].
Norlin JM, Calara PS, Persson U, Schmitt-Egenolf M. Real-world outcomes in 2,646 psoriasis patients: One in five has PASI ≥ 10 and/or DLQI ≥ 10 under ongoing systemic therapy. J Dermatolog Treat. 2017 Jan 30. 1-20. [Medline].
Koek MB, Buskens E, van Weelden H, Steegmans PH, Bruijnzeel-Koomen CA, Sigurdsson V. Home versus outpatient ultraviolet B phototherapy for mild to severe psoriasis: pragmatic multicentre randomised controlled non-inferiority trial (PLUTO study). BMJ. 2009 May 7. 338:b1542. [Medline]. [Full Text].
Shah A, Albrecht J, Bonilla-Martinez Z, Okawa J, Rose M, Rosenbach M, et al. Lenalidomide for the treatment of resistant discoid lupus erythematosus. Arch Dermatol. 2009 Mar. 145(3):303-6. [Medline]. [Full Text].
Panjwani S. Early diagnosis and treatment of discoid lupus erythematosus. J Am Board Fam Med. 2009 Mar-Apr. 22(2):206-13. [Medline].
Lesiak A, Narbutt J, Kobos J, Kordek R, Sysa-Jedrzejowska A, Norval M, et al. Systematic administration of chloroquine in discoid lupus erythematosus reduces skin lesions via inhibition of angiogenesis. Clin Exp Dermatol. 2009 Jul. 34(5):570-5. [Medline].
Brems H, Beert E, de Ravel T, Legius E. Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1. Lancet Oncol. 2009 May. 10(5):508-15. [Medline].
Oliveira TM, Sakai VT, Candido LA, Silva SM, Machado MA. Clinical management for epidermolysis bullosa dystrophica. J Appl Oral Sci. 2008 Jan-Feb. 16(1):81-5. [Medline].
Fantauzzi RS, Maia MO, Cunha FC, Simões RV, Gonçalves DU, Maia AF. Otorhinolaryngological and esophageal manifestations of epidermolysis bullosa. Braz J Otorhinolaryngol. 2008 Sep-Oct. 74(5):657-61. [Medline].
Morava E, Guillard M, Lefeber DJ, Wevers RA. Autosomal recessive cutis laxa syndrome revisited. Eur J Hum Genet. 2009 Sep. 17(9):1099-110. [Medline]. [Full Text].
Mitchell AL, Schwarze U, Jennings JF, Byers PH. Molecular mechanisms of classical Ehlers-Danlos syndrome (EDS). Hum Mutat. 2009 Jun. 30(6):995-1002. [Medline].
Bristow I. Non-ulcerative skin pathologies of the diabetic foot. Diabetes Metab Res Rev. 2008 May-Jun. 24 Suppl 1:S84-9. [Medline].
NilFroushzadeh MA, Siadat AH, Baradaran EH, Moradi S. Clindamycin lotion alone versus combination lotion of clindamycin phosphate plus tretinoin versus combination lotion of clindamycin phosphate plus salicylic acid in the topical treatment of mild to moderate acne vulgaris: a randomized control trial. Indian J Dermatol Venereol Leprol. 2009 May-Jun. 75(3):279-82. [Medline].
Webster G, Cargill DI, Quiring J, Vogelson CT, Slade HB. A combined analysis of 2 randomized clinical studies of tretinoin gel 0.05% for the treatment of acne. Cutis. 2009 Mar. 83(3):146-54. [Medline].
Hanrahan PF, D'Este CA, Menzies SW, Plummer T, Hersey P. A randomised trial of skin photography as an aid to screening skin lesions in older males. J Med Screen. 2002. 9(3):128-32. [Medline].

Media Gallery

Papular benign skin lesion: Acrochordon (skin tag).
Papular benign skin lesion: Pyogenic granuloma.
Papular lesions: Keloids developed from back acne.
Macular benign skin lesions: Seborrheic keratoses of back and trunk.
Macular benign skin lesions: Seborrheic keratoses of the face.
Macular benign skin lesion: Nevus sebaceous of Jadassohn.
Subepidermal lesion: Keratinous cyst (epidermal inclusion cyst).
Subepidermal benign lesion: Lipoma of posterior neck.
Benign pigmented lesion: Dermatosis papulosa nigra.
Psoriasis.
Necrobiosis lipoidica diabeticorum.
Pyoderma gangrenosum.
Common benign skin lesion algorithm. (Concept and original organization courtesy of Scott Bangs, MD, Owatonna Clinic - Mayo Health System)
Papular lesions.
Macular skin-colored lesions.
Pigmented lesions.
Subepidermal lesions.
Anatomy of the skin.
Dermatofibroma
Keratoacanthoma
Keratoacanthoma
Keratoacanthoma

of 22

Author

Ginard I Henry, MD Plastic, Reconstructive, and Hand Surgeon, Stonegate Plastic Surgery, Lakeland Health

Ginard I Henry, MD is a member of the following medical societies: American Medical Association, American Society for Reconstructive Microsurgery, American Society for Surgery of the Hand, American Society of Plastic Surgeons, California Medical Association, Christian Medical and Dental Associations, National Medical Association

Disclosure: Nothing to disclose.

Coauthor(s)

Mark A Grevious, MD, FACS Chairman, Division of Plastic and Reconstructive Surgery, John H Stroger, Jr Hospital of Cook County

Mark A Grevious, MD, FACS is a member of the following medical societies: American College of Surgeons, American Society of Maxillofacial Surgeons, American Society of Plastic Surgeons, Association for Academic Surgery

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Jorge I de la Torre, MD, FACS Professor of Surgery and Physical Medicine and Rehabilitation, Chief, Division of Plastic Surgery, Residency Program Director, University of Alabama at Birmingham School of Medicine; Director, Center for Advanced Surgical Aesthetics

Jorge I de la Torre, MD, FACS is a member of the following medical societies: American Burn Association, American College of Surgeons, American Medical Association, American Society for Laser Medicine and Surgery, American Society of Maxillofacial Surgeons, American Society of Plastic Surgeons, American Society for Reconstructive Microsurgery, Association for Academic Surgery, Medical Association of the State of Alabama

Disclosure: Nothing to disclose.

Chief Editor

Gregory Gary Caputy, MD, PhD, FICS Wound Healing Consultant, Advantage Surgical and Wound Care

Gregory Gary Caputy, MD, PhD, FICS is a member of the following medical societies: American Society for Laser Medicine and Surgery, International College of Surgeons, International College of Surgeons US Section, Wound Healing Society

Disclosure: Nothing to disclose.

Additional Contributors

Andrea Leigh Zaenglein, MD Professor of Dermatology and Pediatrics, Department of Dermatology, Hershey Medical Center, Pennsylvania State University College of Medicine

Andrea Leigh Zaenglein, MD is a member of the following medical societies: American Academy of Dermatology, Society for Pediatric Dermatology

Disclosure: Received consulting fee from Galderma for consulting; Received consulting fee from Valeant for consulting; Received consulting fee from Promius for consulting; Received consulting fee from Anacor for consulting; Received grant/research funds from Stiefel for investigator; Received grant/research funds from Astellas for investigator; Received grant/research funds from Ranbaxy for other; Received consulting fee from Ranbaxy for consulting.

Acknowledgements

The authors and editors of eMedicine gratefully acknowledge the contributions of previous authors Todd A Morton, MD, FACS, and Wayne Karl Stadelmann, MD, to the development and writing of the source article.

What is nevus sebaceus of Jadassohn?

Answer

Related Questions:

About

Membership

Apps

WebMD Network

Editions

What is nevus sebaceus of Jadassohn?

Answer

Related Questions:

References

Tables

Contributor Information and Disclosures

Find Us On

About

Membership

Apps

WebMD Network

Editions