What is the efficacy of cryotherapy in the treatment of keloids?

Updated: Jan 30, 2020
  • Author: Ginard I Henry, MD; Chief Editor: Gregory Gary Caputy, MD, PhD, FICS  more...
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A prospective, multicenter study found that intralesional cryotherapy shrank keloid scar volume by an average of 63% at 1-year follow-up. The study, of 27 patients (29 keloid scars), also determined that patient complaints of pain and pruritus were reduced at follow-up. However, 69% of the keloid scars demonstrated persistent hypopigmentation, with the incidence being highest in African American patients, and 24% of the keloids recurred. [9]

A randomized study by Mourad et al indicated that intralesional cryotherapy is more effective than spray cryotherapy in keloid treatment and requires fewer applications. The study included 50 patients, with a 6-month follow-up. [10]

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