How is keratoacanthoma (KA) classified?

Updated: Jan 30, 2020
  • Author: Ginard I Henry, MD; Chief Editor: Gregory Gary Caputy, MD, PhD, FICS  more...
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Answer

Whether keratoacanthoma can truly be classified as a malignant variant of squamous cell carcinoma, however, remains in question, although based on a systematic review, Savage and Maize concluded that keratoacanthoma cannot be considered as such. Comparing the clinical behaviors of the two lesions as recorded in 445 cases of keratoacanthoma and 429 cases of squamous cell carcinoma, the investigators found that none of keratoacanthomas resulted in distant metastases or death, while squamous cell carcinoma resulted in 61 cases of metastases and was the direct cause of 24 deaths. [6]

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