Which histologic findings are characteristic of amiodarone-associated thyroid dysfunction?

Updated: Aug 28, 2020
  • Author: Mini Gopalan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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A biopsy of the thyroid gland is unnecessary in most patients. The histological changes that occur with amiodarone administration have been studied in a research setting and include the following:

  • Marked follicular disruption by diffuse fibrosis

  • Epithelial atrophy

  • Apoptosis

  • Necrosis

  • Markedly dilated endoplasmic reticulum

  • Intraluminal aggregates of vacuolated cells

  • Foci of nonspecific lymphocyte infiltration

Patients with euthyroidism treated with amiodarone therapy showed minimal or no evidence of thyroid follicular damage.

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