What is the role of nuclear medicine imaging in the diagnosis of amiodarone-associated thyroid dysfunction?

Updated: Aug 28, 2020
  • Author: Mini Gopalan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Most patients with AIH have been reported to have positive results on the perchlorate discharge test, indicating defects in intrathyroidal iodide organification. People with AIT have negative test results. These tests are rarely indicated or performed outside an academic setting.

A study found technetium-99m – sestamibi (99m Tc-MIBI) thyroid scintigraphy to be effective in the differential diagnosis of AIT. [6, 12] According to the report, which utilized patients with either type 1 or type 2 AIT, or with an indefinite form of the condition, this modality proved superior to a variety of diagnostic tools, including color flow Doppler ultrasonography and radioactive iodine, in differentiating one form of AIT from another.


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