What is the upper limit of vitamin D beyond which risk of acute coronary syndrome (ACS) and mortality increase?

Updated: Dec 15, 2020
  • Author: Vin Tangpricha, MD, PhD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
  • Print
Answer

In a population-based study, the electronic medical records of more than 1,200,000 members of a health maintenance organization (HMO) were analyzed to determine the upper limit of vitamin D beyond which there is an increased risk of acute coronary syndrome (ACS) or mortality. [71, 72] The lowest risk of mortality and morbidity was reported in members with vitamin D levels in the 20-36 ng/mL range. [72] The hazard ratio increased not only below but also above this range, with adjusted hazard ratios of 1.88 among subjects with vitamin D levels lower than 10 ng/mL, 1.25 among those with levels of 10-20 ng/mL, and 1.13 among those with levels higher than 36 ng/mL (P < 0.05).


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!